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Chemical Synthesis Reactors

Automation for Every Chemist

Chemical reactors reinvent the way scientists work, enabling the generation of more information per experiment and accelerating the delivery of life-changing products. Automated chemical synthesis reactors are well established in the chemical and pharmaceutical industry, and they are essential to speed up time-to-market cycles at lower R&D costs.

The innovative chemical synthesis reactors EasyMax™ and OptiMax™ are easy-to-use platforms that accurately execute recipes and precisely control reaction parameters, thus enabling highly reproducible reactions. Experiment procedures can be run unattended around the clock, and all data is automatically recorded, and ready to be instantly shared.

automated chemical synthesis reactors

automated chemical synthesis reactors
automated chemical synthesis reactors

chemical reactor automation

chemical reactor automation
chemical reactor automation

Repeatable Chemistry around the Clock

Based on our partnerships with leading scientists, we understand the challenges faced in chemical labs. Our chemical reactors are designed to minimize bottlenecks and maximize efficiency. 

More than ever, scientists are looking to automate tedious and manual chemical synthesis procedures. Automation of reaction conditions, experiment controls, and data collection increases personal productivity while ensuring safe operations day and night.

chemical synthesis reactors product catalog

Custom Workstations for Seamless Chemical Synthesis

With reactor volumes ranging from lab to plant scale, we offer a comprehensive selection of chemical synthesis equipment and accessories to meet your unique application:

  • Reactor sets (glass and PTFE, one and two-piece, pressure)
  • Dosing sets and syringes
  • Overhead stirrers and more!

View the Full Synthesis Workstations Product Catalog

chemical reactor automation

chemical reactor automation
chemical reactor automation

Chemistries at Subambient Temperature​

EasyMax™ chemical synthesis reactors in LowTemp (LT) reactor models expand the temperature design space down to -90°C. This helps you both design reactions including organometallic metalation and lithiation reactions and optimize processes at subambient conditions, paving the way for the discovery of new synthetic pathways.

Unlike traditional equipment with discrete temperatures at 0°C, -21°C (sodium chloride in ice), and -78°C (acetone/dry ice), our low temp reactors precisely control experimental conditions along a broad temperature range – even when unattended.​

reactor vessels

Synthesis Reactors to Fit Your Chemistry

Discover breakthrough molecules and explore novel synthetic steps. With a broad application range, automated chemical reactors pose no limits on your creativity and productivity in the chemical synthesis laboratory. Reactor volumes range from 8 ml tubes to 1 L vessels, and one- or two-piece reactors fit your chemistry and workflow.

Chemical synthesis reactors operate at temperatures from -90°C to 180°C and offer overhead and magnetic stirring, as well as vacuum, ambient and high-pressure chemistry, making it easy and enjoyable to solve complex chemistry problems.

optimax viewing

Ensure Safe, Robust, and Scalable Processes

OptiMax™ lab reactor systems are designed to ensure safe, robust, and scalable processes. Researchers can characterize and optimize chemical reactions on the liter scale before going to manufacturing. OptiMax™ chemical reactors are applied for go/no-go safety considerations when scaling up by identifying enthalpy, heat capacity, heat, and mass transfer under process-like conditions. The synthesis reactors are widely applied when engineering particles by (re)crystallization with particle size analyzers.

safe chemical synthesis

Sustain a Culture of Safety with Chemical Reactors

Solutions that enable a culture of safety must fulfill the needs of every scientist, minimize all risks to ensure maximum personal safety, enable the development of process conditions that match large-scale operations, and assess hazards to predict the risks of a process.

We developed EasyMax™, a chemical reaction workstation that helps maximize personal safety in the laboratory by controlling preprogrammed reactions safely and automatically to limit or eliminate chemical exposure. Reduce exposure risk and design processes that are inherently safer.

chemical synthesis workstation

Innovation Starts with Understanding

Every scientist needs to gain information to answer critical questions when innovating molecules, optimizing reaction routes, and creating robust and safe processes. METTLER TOLEDO chemical synthesis reactors integrate seamlessly with in-situ probes, including the EasySampler automated sampling system, ReactIR FTIR spectrometers, and particle size analyzers. The consolidated data stream of reaction parameters together with information on kinetics, reaction mechanisms, impurity profiles, and particle attributes provides critical answers when adapting lab processes to the plant. The integrated solution enables scientists to deliver life-changing products faster and more cost-efficiently.

What is a chemical synthesis reactor?

Chemical synthesis reactors are vessels in which chemical reactions take place. Reaction parameters, such as temperature, dosing, stirring, and sampling, are set to perform a synthesis reaction. The accuracy and precision of those reaction parameters play an important role in the selectivity, conversion, and reproducibility of the chemical reaction.

What are the types of chemical synthesis reactors?

There are three types of chemical reactors:

  1. Batch reactors
  2. Continuous stirred-tank reactors (CSTR)
  3. Plug flow reactors (PFR)

Batch reactors are stirred tank reactors where the chemical reaction occurs in a confined space over a period of time.

Continuous stirred-tank reactors, or semi-batch reactors, have reactants continuously added and (by)products are removed.

Plug-flow reactors are usually tubular reactors, where the conversion of chemical reactions is influenced by residential time.

What are the challenges with traditional synthesis reactor equipment?

The preparation of manual lab equipment tends to be cumbersome and slow while putting the scientist at risk of exposure. Traditional setups also tend to be poorly controlled when it comes to limiting the reaction parameter range, including T, p, pH, and sampling, which risks inconsistent and non-reproducible results. Information gaps limit understanding if data is not recorded or documentation is lost.

How can I automate my lab reactor?

chemical reactor control system

METTLER TOLEDO automated chemical synthesis reactor systems are designed for quick start-up, easy handling, precise control, intrinsic safety, and seamless data analysis and reporting.

  • Initiate recipes from the preconfigured home screen touchscreen or software.
  • Control reaction parameters from touchscreen or software, assuring better data quality and complete data sets.
  • Automate active cooling to allow fast temperature control and avoid unexpected side products. 
  • Automate data export to share visualization and traceability of results when you need them.

Additionally, the RX-10 reactor control system can connect to your existing jacketed lab reactor to automate cumbersome tasks for those who do not need full workstation setups. This reactor control system uses the same touchscreen interface as the full workstations for seamless workflows.

Do METTLER TOLEDO chemical synthesis reactors support Design of Experiment (DoE)?

doe design of experiments

doe design of experiments
doe design of experiments

Because our chemical synthesis reactors are designed to minimize bottlenecks and maximize the efficiency of the chemical laboratory, our models easily enable Design of Experiment (DoE) studies to produce high-quality experimental data. You can use METTLER TOLEDO reactors to optimize reaction and process parameters and explore how various combinations of settings such as temperature, pH, dosing, and stirring affect outcomes.

What is the difference between Basic and Advanced models?

EasyMax Advanced offers more features than its Basic counterpart. The Advanced personal synthesis workstation offers a more comprehensive information management platform, including graph trends and task sequences on the touchscreen and full data capture/experiment documentation. You can also easily integrate and add the capabilities of:

  • iC Data Center™ software, to share data and build institutional knowledge
  • iControl™ software for planning, advanced control, and data evaluation
  • Heat flow calorimetry for process safety screening to identify, eliminate, and correct non-scalable reaction conditions

The 102 and 402 designations indicate the maximum volume and number of reactors available in the given workstation (i.e. 102 = up to two 100 ml vessels, while 402 = up to two 400 ml vessels)

See all Basic and Advanced models:

Can I connect my reactor to third party accessories?

chemical synthesis reactor workstation

Yes! Extend your reactor for automated control and data capture of 3rd party devices including sensors and dosing/sampling solutions with the Easy Control Box (ECB) accessory, purchased separately.

ECB provides dosing control capabilities and easily connects commercially available pumps and balances for automated pre-programmed gravimetric or volumetric dosing. The accessory has plug-and-measure functionality with SmartConnect technology sensors. Control elements are automatically recognized, making reactor configuration simple and easy.  

Learn more about Easy Control Box (ECB).

Journey to the New Normal

Journey to the New Normal

Overcoming Unexpected Productivity Upsets in Chemical Development

Det moderne synteselaboratoriet

Det moderne synteselaboratoriet

En ny arbeidsplass for kjemikere

Safe, Unattended Dosing in Chemical Development & Scale-up

Safe, Unattended Dosing in Chemical Development & Scale-up

Automate Dosing and Run Highly Exothermic Reactions Unattended

Viral Inactivation in Bioprocess Development

Viral Inactivation in Bioprocess Development

Automated Solutions for Optimization and Control of Low pH Viral Inactivation

Oppretthold en sikkerhetskultur

Oppretthold en sikkerhetskultur

Bygg person-, prosess- og miljøsikkerhet inn i hvert eksperiment

Guide to Chemical Process Safety

Guide to Chemical Process Safety

Understand the Risks - Safe Chemical Processes at Scale